Abdool Karim, an infectious diseases epidemiologist and Assoc. Sci. Dir. of CAPRISA, focuses on evolving HIV epidemic; factors influencing HIV acquisition, interventions to reduce HIV infection in young women; and novel strategies to introduce AIDS treatment in high disease burden settings. Her landmark CAPRISA 004 tenofovir gel study provided the first evidence for the use of anti-retrovirals to prevent HIV infection. Published in Science, it has over 1500 citations. She is Professor in Clinical Epidemiology, Mailman School of Public Health, Columbia U., and in Public Health, Nelson R Mandela School of Medicine, U. of KwaZulu-Natal. Her awards include: 2014 TWAS-Lenovo Prize; Order of Mapungubwe, South Africa’s highest honour, 216 L'Oreal-Unesco Laureate (Africa & Middle East). She is a member of: US Natl. Acad. of Medicine; African Acad. of Science (Vice-Pres.); Acad. of Science of South Africa; Royal Soc. of South Africa.